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Scans from Group 2 showed a significant reduction of artifacts (p=0.01), compared to Group 1.

Statistical significance was assessed by a two sample t-test with an alpha level of 0.05.ģ0 diseased eyes were imaged (15 per group). The superficial retinal layer slab of each scan was analyzed with this metric, and the average displacement across the image was used to compare the two groups. Given that in dense OCTA cubes neighboring B-scans have similar vessel morphology, a custom algorithm quantified vessel jaggedness by computing the normalized cross-correlation and lateral displacement between consecutive B-scans. 14 normal eyes were scanned using both LSO configurations while the subject was asked to repeat a systematic eye motion pattern during acquisition.

In addition to the higher resolution LSO, Group 2 also used an improved version of the FastTrac TM algorithm. Diseased subjects were imaged using one of two acquisition settings:ġ) Group 1 (n=15): An LSO with 50µm x 40µm tracking resolutionĢ) Group 2 (n=15): An LSO with 25µm x 25µm tracking resolution PLEX ® Elite 9000 (ZEISS, Dublin, CA) with LSO-based tracking was used to acquire 3x3mm OCTA scans, centered at the fovea, on normal eyes and eyes with retinal disease. We analyzed the effects of fundus tracking resolution on these common artifacts.

Errors in such corrections can lead to artifacts in the OCTA enface image, visible as vessel jaggedness. Line Scan Ophthalmoscopes (LSO) are commonly used in Optical Coherence Tomography Angiography (OCTA) systems to image the fundus of the eye in order to track and correct for motion.